Preheat oven to 400°F. Spray an 8x8-inch baking pan with cooking spray and set aside.
Remove fat from chicken and cut into 8 even pieces (use a food scale if possible; each piece should weigh 2 ounces). Season chicken on all sides with salt and pepper.
Set out 2 bowls. Place 1/3 cup Alfredo sauce in one. In the other, place panko, freshly grated Parmesan cheese, Italian seasoning, garlic powder, and a pinch of salt and pepper.
Dredge each chicken piece in the Alfredo and then in the panko mixture. Place chicken pieces in the prepared pan.
Bake uncovered for 20 minutes.
Remove and cover with 2/3 cup Alfredo sauce and 1/2 cup freshly grated mozzarella cheese.
Return to oven and bake for another 8–10 minutes, or until chicken is completely cooked through (thermometer reads 160°F). Remove and serve. Grate additional Parmesan cheese on top.
Video
Notes
Storage: Store leftovers in an airtight container in the fridge for up to 3 days. Reheat in the oven or microwave until warmed through.